Pesquisa | Biblioteca Virtual em Saúde

1.

APOE3ch alters microglial response and suppresses Aß-induced tau seeding and spread.

Chen, Yun; Song, Sihui; Parhizkar, Samira; Lord, Jennifer; Zhu, Yiyang; Strickland, Michael R; Wang, Chanung; Park, Jiyu; Tabor, G Travis; Jiang, Hong; Li, Kevin; Davis, Albert A; Yuede, Carla M; Colonna, Marco; Ulrich, Jason D; Holtzman, David M.

Cell ; 187(2): 428-445.e20, 2024 01 18.

Artigo em Inglês | MEDLINE | ID: mdl-38086389

2.

Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma.

Kirschenbaum, Daniel; Xie, Ken; Ingelfinger, Florian; Katzenelenbogen, Yonatan; Abadie, Kathleen; Look, Thomas; Sheban, Fadi; Phan, Truong San; Li, Baoguo; Zwicky, Pascale; Yofe, Ido; David, Eyal; Mazuz, Kfir; Hou, Jinchao; Chen, Yun; Shaim, Hila; Shanley, Mayra; Becker, Soeren; Qian, Jiawen; Colonna, Marco; Ginhoux, Florent; Rezvani, Katayoun; Theis, Fabian J; Yosef, Nir; Weiss, Tobias; Weiner, Assaf; Amit, Ido.

Cell ; 187(1): 149-165.e23, 2024 01 04.

Artigo em Inglês | MEDLINE | ID: mdl-38134933

3.

Flux regulation through glycolysis and respiration is balanced by inositol pyrophosphates in yeast.

Qin, Ning; Li, Lingyun; Ji, Xu; Pereira, Rui; Chen, Yu; Yin, Shile; Li, Chaokun; Wan, Xiaozhen; Qiu, Danye; Jiang, Junfeng; Luo, Hao; Zhang, Yueping; Dong, Genlai; Zhang, Yiming; Shi, Shuobo; Jessen, Henning J; Xia, Jianye; Chen, Yun; Larsson, Christer; Tan, Tianwei; Liu, Zihe; Nielsen, Jens.

Cell ; 186(4): 748-763.e15, 2023 02 16.

Artigo em Inglês | MEDLINE | ID: mdl-36758548

4.

An immune cell atlas reveals the dynamics of human macrophage specification during prenatal development.

Wang, Zeshuai; Wu, Zhisheng; Wang, Hao; Feng, Ruoqing; Wang, Guanlin; Li, Muxi; Wang, Shuang-Yin; Chen, Xiaoyan; Su, Yiyi; Wang, Jun; Zhang, Weiwen; Bao, Yuzhou; Lan, Zhenwei; Song, Zhuo; Wang, Yiheng; Luo, Xianyang; Zhao, Lingyu; Hou, Anli; Tian, Shuye; Gao, Hongliang; Miao, Wenbin; Liu, Yingyu; Wang, Huilin; Yin, Cui; Ji, Zhi-Liang; Feng, Mingqian; Liu, Hongkun; Diao, Lianghui; Amit, Ido; Chen, Yun; Zeng, Yong; Ginhoux, Florent; Wu, Xueqing; Zhu, Yuanfang; Li, Hanjie.

Cell ; 186(20): 4454-4471.e19, 2023 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-37703875

5.

HGT is widespread in insects and contributes to male courtship in lepidopterans.

Li, Yang; Liu, Zhiguo; Liu, Chao; Shi, Zheyi; Pang, Lan; Chen, Chuzhen; Chen, Yun; Pan, Ronghui; Zhou, Wenwu; Chen, Xue-Xin; Rokas, Antonis; Huang, Jianhua; Shen, Xing-Xing.

Cell ; 185(16): 2975-2987.e10, 2022 08 04.

Artigo em Inglês | MEDLINE | ID: mdl-35853453

6.

TREM2 drives microglia response to amyloid-ß via SYK-dependent and -independent pathways.

Wang, Shoutang; Sudan, Raki; Peng, Vincent; Zhou, Yingyue; Du, Siling; Yuede, Carla M; Lei, Tingting; Hou, Jinchao; Cai, Zhangying; Cella, Marina; Nguyen, Khai; Poliani, Pietro L; Beatty, Wandy L; Chen, Yun; Cao, Siyan; Lin, Kent; Rodrigues, Cecilia; Ellebedy, Ali H; Gilfillan, Susan; Brown, Gordon D; Holtzman, David M; Brioschi, Simone; Colonna, Marco.

Cell ; 185(22): 4153-4169.e19, 2022 10 27.

Artigo em Inglês | MEDLINE | ID: mdl-36306735

7.

Targeting JMJD1C to selectively disrupt tumor T_reg cell fitness enhances antitumor immunity.

Long, Xuehui; Zhang, Sulin; Wang, Yuliang; Chen, Jingjing; Lu, Yanlai; Hou, Hui; Lin, Bichun; Li, Xutong; Shen, Chang; Yang, Ruirui; Zhu, Huamin; Cui, Rongrong; Cao, Duanhua; Chen, Geng; Wang, Dan; Chen, Yun; Zhai, Sulan; Zeng, Zhiqin; Wu, Shusheng; Lou, Mengting; Chen, Junhong; Zou, Jian; Zheng, Mingyue; Qin, Jun; Wang, Xiaoming.

Nat Immunol ; 25(3): 525-536, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38356061

8.

Microglia esprit de corps: Sharing the burden of eliminating toxic aggregates.

Chen, Yun; Colonna, Marco.

Cell ; 184(20): 5082-5084, 2021 09 30.

Artigo em Inglês | MEDLINE | ID: mdl-34597598

9.

TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy.

Molgora, Martina; Esaulova, Ekaterina; Vermi, William; Hou, Jinchao; Chen, Yun; Luo, Jingqin; Brioschi, Simone; Bugatti, Mattia; Omodei, Andrea Salvatore; Ricci, Biancamaria; Fronick, Catrina; Panda, Santosh K; Takeuchi, Yoshiko; Gubin, Matthew M; Faccio, Roberta; Cella, Marina; Gilfillan, Susan; Unanue, Emil R; Artyomov, Maxim N; Schreiber, Robert D; Colonna, Marco.

Cell ; 182(4): 886-900.e17, 2020 08 20.

Artigo em Inglês | MEDLINE | ID: mdl-32783918

10.

Jmjd1c demethylates STAT3 to restrain plasma cell differentiation and rheumatoid arthritis.

Yin, Yuye; Yang, Xinyi; Wu, Shusheng; Ding, Xinyu; Zhu, Huamin; Long, Xuehui; Wang, Yuliang; Zhai, Sulan; Chen, Yun; Che, Nan; Chen, Jingjing; Wang, Xiaoming.

Nat Immunol ; 23(9): 1342-1354, 2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-35995859

11.

Human retinoic acid-regulated CD161⁺ regulatory T cells support wound repair in intestinal mucosa.

Povoleri, Giovanni A M; Nova-Lamperti, Estefania; Scottà, Cristiano; Fanelli, Giorgia; Chen, Yun-Ching; Becker, Pablo D; Boardman, Dominic; Costantini, Benedetta; Romano, Marco; Pavlidis, Polychronis; McGregor, Reuben; Pantazi, Eirini; Chauss, Daniel; Sun, Hong-Wei; Shih, Han-Yu; Cousins, David J; Cooper, Nichola; Powell, Nick; Kemper, Claudia; Pirooznia, Mehdi; Laurence, Arian; Kordasti, Shahram; Kazemian, Majid; Lombardi, Giovanna; Afzali, Behdad.

Nat Immunol ; 19(12): 1403-1414, 2018 12.

Artigo em Inglês | MEDLINE | ID: mdl-30397350

12.

Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains.

Song, Bin; Chen, Yun; Liu, Xin; Yuan, Fei; Tan, Eddie Yong Jun; Lei, Yixuan; Song, Ning; Han, Yinqi; Pascal, Bruce D; Griffin, Patrick R; Luo, Cheng; Wu, Bin; Luo, Dahai; Zheng, Jie.

Immunity ; 54(10): 2218-2230.e5, 2021 10 12.

Artigo em Inglês | MEDLINE | ID: mdl-34644557

13.

Structure of an activated DNA-PK and its implications for NHEJ.

Chen, Xuemin; Xu, Xiang; Chen, Yun; Cheung, Joyce C; Wang, Huaibin; Jiang, Jiansen; de Val, Natalia; Fox, Tara; Gellert, Martin; Yang, Wei.

Mol Cell ; 81(4): 801-810.e3, 2021 02 18.

Artigo em Inglês | MEDLINE | ID: mdl-33385326

14.

The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors.

Lian, Huan; Zang, Ru; Wei, Jin; Ye, Wen; Hu, Ming-Ming; Chen, Yun-Da; Zhang, Xia-Nan; Guo, Yi; Lei, Cao-Qi; Yang, Qing; Luo, Wei-Wei; Li, Shu; Shu, Hong-Bing.

Immunity ; 49(3): 438-448.e5, 2018 09 18.

Artigo em Inglês | MEDLINE | ID: mdl-30193849

15.

An engineered IL-2 partial agonist promotes CD8⁺ T cell stemness.

Mo, Fei; Yu, Zhiya; Li, Peng; Oh, Jangsuk; Spolski, Rosanne; Zhao, Liang; Glassman, Caleb R; Yamamoto, Tori N; Chen, Yun; Golebiowski, Filip M; Hermans, Dalton; Majri-Morrison, Sonia; Picton, Lora K; Liao, Wei; Ren, Min; Zhuang, Xiaoxuan; Mitra, Suman; Lin, Jian-Xin; Gattinoni, Luca; Powell, Jonathan D; Restifo, Nicholas P; Garcia, K Christopher; Leonard, Warren J.

Nature ; 597(7877): 544-548, 2021 09.

Artigo em Inglês | MEDLINE | ID: mdl-34526724

16.

Microbial pattern recognition suppresses de novo organogenesis.

Tran, Sorrel; Stephanie Chen, Yun-Fan; Xu, Dawei; Ison, Madalene; Yang, Li.

Development ; 150(9)2023 05 01.

Artigo em Inglês | MEDLINE | ID: mdl-37073949

17.

Overproduction of mycotoxin biosynthetic enzymes triggers Fusarium toxisome-shaped structure formation via endoplasmic reticulum remodeling.

Wang, Minhui; Wu, Ningjie; Wang, Huiyuan; Liu, Chang; Chen, Qiaowan; Xu, Tianming; Chen, Yun; Zhao, Youfu; Ma, Zhonghua.

PLoS Pathog ; 20(1): e1011913, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-38166144

18.

Proteomic Analysis Revealed the Potential Role of MAGE-D2 in the Therapeutic Targeting of Triple-Negative Breast Cancer.

Shi, Xiaoyu; Liu, Chunyan; Zheng, Weimin; Cao, Xiao; Li, Wan; Zhang, Dongxue; Zhu, Jianhua; Zhang, Xian; Chen, Yun.

Mol Cell Proteomics ; 23(1): 100703, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-38128647

19.

The jet-like chromatin structure defines active secondary metabolism in fungi.

Shao, Wenyong; Wang, Jingrui; Zhang, Yueqi; Zhang, Chaofan; Chen, Jie; Chen, Yun; Fei, Zhangjun; Ma, Zhonghua; Sun, Xuepeng; Jiao, Chen.

Nucleic Acids Res ; 2024 Feb 26.

Artigo em Inglês | MEDLINE | ID: mdl-38407438

20.

Migration and division in cell monolayers on substrates with topological defects.

Kaiyrbekov, Kurmanbek; Endresen, Kirsten; Sullivan, Kyle; Zheng, Zhaofei; Chen, Yun; Serra, Francesca; Camley, Brian A.

Proc Natl Acad Sci U S A ; 120(30): e2301197120, 2023 07 25.

Artigo em Inglês | MEDLINE | ID: mdl-37463218

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